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By Alton Meister

Advances in Enzymology and similar components of Molecular Biology is a seminal sequence within the box of biochemistry, supplying researchers entry to authoritative studies of the most recent discoveries in all components of enzymology and molecular biology. those landmark volumes date again to 1941, supplying an unequalled view of the ancient improvement of enzymology. The sequence bargains researchers the most recent knowing of enzymes, their mechanisms, reactions and evolution, roles in complicated organic strategy, and their software in either the laboratory and undefined. each one quantity within the sequence positive factors contributions by means of top pioneers and investigators within the box from worldwide. All articles are rigorously edited to make sure thoroughness, caliber, and clarity.

With its wide selection of themes and lengthy ancient pedigree, Advances in Enzymology and comparable components of Molecular Biology can be utilized not just through scholars and researchers in molecular biology, biochemistry, and enzymology, but additionally by way of any scientist drawn to the invention of an enzyme, its houses, and its applications.

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Thus the essential role of the agonist-receptor complex is t o promote the exchange of diphosphate for a triphosphate on the nucleotide regulatory protein in accordance with the work of Cassel and Selinger (76). HORMONE RECEPTOR-ADENYLATE CYCLASE SYSTEMS 35 One intriguing and as yet not fully explained phenomenon is the enhancement of the agonist-promoted GDP release from the nucleotide regulatory protein in the presence of added guanine nucleotide (76). This concerted exchange mechanism could be explained by a dimeric or oligomeric nature of the nuclecitide regulatory protein.

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252, 2455 (1977). 75. Gill, D. ,Proc. Natl. Acad. Sci. ,75, 3050 (1978). 76. , and Selinger, Z . , Proc. Natl. Acad. Sci. , 75, 4155 (1978). 77. , J. , 3 , 393 (1977). 78. , J. Biol. , 252, 7224 (1977). 79. ,Proc. Natl. Acad. Sci. , 75, 2669 (1978). 80. , J. Biol. , 254, 9829 (1979). 81. Downs, R. , Spiegel, A. , and Aurbach, G. , J. Biol. , 255, 749 (1980). 82. Johnson, G. , Kaslow, H. , and Bourne, H. , J. Biol. , 253, 7120 (1978). 83. Kaslow, H. , Farfel, Z . , Johnson, G. , and Bourne, H.

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